Chemical Constituents and Biological Screening of Grewia optiva Drummond ex Burret Whole Plant

Grewia optiva, a plant of northern area of Pakistan was screened for the natural products, antimicrobial and insecticidal activities. Phytochemical screening, using conventional natural products identification tests indicated the presence of different phytoconstituents. The ethyl acetate and methanolic extracts of the aerial parts of the tile plant revealed the presence of tannins, while terpenoids, flavonoids and steroids were present in n-hexane and chloroform fractions. n-hex.+ethyl acetate soluble fraction indicated the presence of saponins and tannins, while n-hexane and n-hexane+ethyl acetate insoluble fractions contained steroids, terpenoids, flavonoids and tannins. Ethyl acetate and n-hexane extract of aerial part is the most active, showing activity against four selected bacterial stains and thus displayed inhibitory zone of (13:0 mm) at the tested concentration (28 mg/ml). The n-hexane and n-hex.+ethyl acetate soluble extracts showed activity with inhibition zone of (13:0 mm) at the tested concentration (32 mg/ml). The n-hexane fraction and n-hex,+EtOAc soluble fractions showed some activity against selected fungal strains. The n-hex.+ethyl acetate soluble extract showed moderate insecticidal activity against Callosbruchus analis with 40 percent mortality rate. The medicinal values of Grewia optiva may be attributed due to the presence of detected metabolites.